Biomaterials-based formulations and surfaces to combat viral infectious diseases

Kumari, S and Chatterjee, K (2021) Biomaterials-based formulations and surfaces to combat viral infectious diseases. In: APL Bioengineering, 5 (1).

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Abstract

Rapidly growing viral infections are potent risks to public health worldwide. Accessible virus-specific antiviral vaccines and drugs are therapeutically inert to emerging viruses, such as Zika, Ebola, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, discovering ways to prevent and control viral infections is among the foremost medical challenge of our time. Recently, innovative technologies are emerging that involve the development of new biomaterial-based formulations and surfaces endowed with broad-spectrum antiviral properties. Here, we review emerging biomaterials technologies for controlling viral infections. Relevant advances in biomaterials employed with nanotechnology to inactivate viruses or to inhibit virus replication and further their translation in safe and effective antiviral formulations in clinical trials are discussed. We have included antiviral approaches based on both organic and inorganic nanoparticles (NPs), which offer many advantages over molecular medicine. An insight into the development of immunomodulatory scaffolds in designing new platforms for personalized vaccines is also considered. Substantial research on natural products and herbal medicines and their potential in novel antiviral drugs are discussed. Furthermore, to control contagious viral infections, i.e., to reduce the viral load on surfaces, current strategies focusing on biomimetic anti-adhesive surfaces through nanostructured topography and hydrophobic surface modification techniques are introduced. Biomaterial surfaces functionalized with antimicrobial polymers and nanoparticles against viral infections are also discussed. We recognize the importance of research on antiviral biomaterials and present potential strategies for future directions in applying these biomaterial-based approaches to control viral infections and SARS-CoV-2. © 2021 Author(s).

Item Type:	Journal Article
Publication:	APL Bioengineering
Publisher:	American Institute of Physics Inc.
Additional Information:	The copyright of this article belongs to American Institute of Physics Inc.
Keywords:	Adhesives; Biomimetics; Controlled drug delivery; Health risks; Hydrophobicity; Nanoparticles; Public risks; Surface chemistry; Topography; Vaccines; Viruses, Anti-adhesive surfaces; Antimicrobial polymers; Antiviral properties; Biomaterial surfaces; Hydrophobic surfaces; Innovative technology; Inorganic nanoparticle; Severe acute respiratory syndrome coronavirus, Diseases
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	11 Mar 2021 09:31
Last Modified:	11 Mar 2021 09:31
URI:	http://eprints.iisc.ac.in/id/eprint/68181

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