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The Role of Cytoskeleton of a Red Blood Cell in Its Deformability

Paradkar, S and Gambhire, P (2021) The Role of Cytoskeleton of a Red Blood Cell in Its Deformability. In: Journal of the Indian Institute of Science .

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Official URL: https://dx.doi.org/10.1007/s41745-020-00221-1


The red blood cell (RBC) is unique in terms of its structure and function when compared to other cells in the blood and body. Its anucleated characteristic and biconcave shape (indicative of high surface area to volume ratio) render it deformable. This deformability is useful during circulation when the red blood cell has to traverse capillaries smaller than its size. The cytoskeleton of the red blood cell, a two dimensional sheet like structure with dynamic linkages, plays a major role in its deformability. The interdependent relationship between the cytoskeleton and RBC deformability under various conditions such as metabolism, hematologic and systemic disorders and senescence is reviewed. © 2021, Indian Institute of Science.

Item Type: Journal Article
Publication: Journal of the Indian Institute of Science
Publisher: Springer
Additional Information: The copyright of this article belongs to Springer
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 23 Feb 2021 08:03
Last Modified: 23 Feb 2021 08:03
URI: http://eprints.iisc.ac.in/id/eprint/68024

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