XCT 790 is a pharmacological aggrephagy inducer in a yeast model of proteotoxicity

Suresh, SN and Jayaprakash Rao, M and Manjithaya, R (2021) XCT 790 is a pharmacological aggrephagy inducer in a yeast model of proteotoxicity. In: Cell Biology International .

	PDF cel_bio_int_2021.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy
	Image (TIFF) cbin11518-sup-0001-fig_s1.tif - Published Supplemental Material Restricted to Registered users only Download (1MB) | Request a copy
	Image (TIFF) cbin11518-sup-0002-fig_s2.tif - Published Version Restricted to Registered users only Download (1MB) | Request a copy
	Image (TIFF) cbin11518-sup-0003-fig_s3.tif - Published Supplemental Material Restricted to Registered users only Download (659kB) | Request a copy
	Microsoft Word cbin11518-sup-0004-supmat.doc - Published Supplemental Material Restricted to Registered users only Download (42kB) | Request a copy

Abstract

Aggrephagy is a selective autophagic degradation intracellular mechanism that clears toxic misfolded protein aggregates such as α-synuclein. Here, we identify and demonstrate that the small molecule, XCT 790 alleviates α-synuclein-mediated adverse effects in a yeast model of proteotoxicity. XCT 790 induced general autophagy and also enhanced starvation-induced autophagy. Mechanistically, we showed that XCT 790 clears toxic α-synuclein aggregates in an autophagy-dependent manner. Interestingly, XCT 790 did not demonstrate a synergistic effect on autophagy induction in the presence of another autophagy inducer such as 6-Bio. © 2021 International Federation for Cell Biology

Item Type:	Journal Article
Publication:	Cell Biology International
Publisher:	Blackwell Publishing Ltd
Additional Information:	The copyright of this article belongs to Blackwell Publishing Ltd
Department/Centre:	Autonomous Societies / Centres > Centre for Brain Research
Date Deposited:	16 Feb 2021 05:17
Last Modified:	16 Feb 2021 05:17
URI:	http://eprints.iisc.ac.in/id/eprint/67964

Actions (login required)

View Item