Chemistry of Tetrathiomolybdate and Tetraselenotungstate: Applications in Carbohydrate and Peptide Chemistry

Sridhar, Perali Ramu (2004) Chemistry of Tetrathiomolybdate and Tetraselenotungstate: Applications in Carbohydrate and Peptide Chemistry. In: Synlett, 2004 (4). pp. 744-745.

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Abstract

(A) The first report on the application of tetrathiomolybdate, $MoS_4 ^{2,-} 1$ in carbohydrate chemistry appeared in 1997 towards the synthesis of sugar disulfides. More recently use of tetraselenotungstate, $WSe_4 ^{2,-} 2$ towards the synthesis of sugar diselenides has been published. The reagents 1 or 2 work very well for the synthesis of disulfides and diselenides respectively from the corresponding sugar halides. (B) The formation of disulfides and diselenides has been applied in the efficient synthesis of cystine, selenocystine, and their higher homologues like homo and bis-homo amino acid derivatives from natural amino acids. The generality of the reaction has been studied by capping various groups to amino and carboxyl components of canonical amino acids.

Item Type:	Journal Article
Publication:	Synlett
Publisher:	Georg Thieme Verlag
Additional Information:	The copyright belongs to Georg Thieme Verlag.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	31 May 2006
Last Modified:	19 Sep 2010 04:26
URI:	http://eprints.iisc.ac.in/id/eprint/6796

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