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A review on hydroxyapatite coatings for the biomedical applications: Experimental and theoretical perspectives

Awasthi, S and Pandey, SK and Arunan, E and Srivastava, C (2021) A review on hydroxyapatite coatings for the biomedical applications: Experimental and theoretical perspectives. In: Journal of Materials Chemistry B, 9 (2). pp. 228-249.

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Official URL: https://dx.doi.org/10.1039/d0tb02407d


The production of hydroxyapatite (HAP) composite coatings has continuously been investigated for bone tissue applications during the last few decades due to their significant bioactivity and osteoconductivity. Herein, we highlight the recent experimental and theoretical progresses on HAP coatings, which may bridge the existing gap between theory and practice. The experimental studies mainly deal with electrochemical (EC) and electrophoretic (EP) deposition for the synthesis of nano-HAP in the form of coatings. Additionally, the biocompatible coating method for the fabrication of HAP composite coatings, the plasma spraying (PS) technique, and its mechanism are discussed in this review. Furthermore, the adhesion strength, mechanical, tribological and electrochemical phenomena of HAP composite coatings are critically analyzed. Their ameliorated bactericidal activity is also discussed to recognize the possibility of substituted HAP coatings from a clinical perspective. In addition, computational studies on the HAP system are explored in this report, including the first-principles density functional theory, ab initio modeling and molecular dynamics simulations. Thus, the main significance of this review is to present a collective discussion on the structural features, interfacial mechanics and binding aspects by experimental and theoretical investigations for HAP-based biomaterials, which can provide clear insights for the future research related to orthopedic applications. This journal is © The Royal Society of Chemistry.

Item Type: Journal Article
Publication: Journal of Materials Chemistry B
Publisher: Royal Society of Chemistry
Additional Information: The copyright of this article belongs to Royal Society of Chemistry
Keywords: Biocompatibility; Computation theory; Computational chemistry; Density functional theory; Electrophoretic coatings; Hydroxyapatite; Medical applications; Molecular dynamics; Plasma spraying, Biocompatible coatings; Biomedical applications; Electrochemical phenomena; First-principles density functional theory; Hydroxyapatite coating; Molecular dynamics simulations; Orthopedic applications; Theoretical investigations, Composite coatings
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 15 Feb 2021 06:26
Last Modified: 15 Feb 2021 06:26
URI: http://eprints.iisc.ac.in/id/eprint/67936

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