Marf-mediated mitochondrial fusion is imperative for the development and functioning of indirect flight muscles (IFMs) in drosophila

Katti, P and Rai, M and Srivastava, S and Silva, PD and Nongthomba, U (2021) Marf-mediated mitochondrial fusion is imperative for the development and functioning of indirect flight muscles (IFMs) in drosophila. In: Experimental Cell Research, 399 (2).

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Abstract

Dynamic changes in mitochondrial shape and size are vital for mitochondrial health and for tissue development and function. Adult Drosophila indirect flight muscles contain densely packed mitochondria. We show here that mitochondrial fusion is critical during early muscle development (in pupa) and that silencing of the outer mitochondrial membrane fusion gene, Marf, in muscles results in smaller mitochondria that are functionally defective. This leads to abnormal muscle development resulting in muscle dysfunction in adult flies. However, post-developmental silencing of Marf has no obvious effects on mitochondrial and muscle phenotype in adult flies, indicating the importance of mitochondrial fusion during early muscle development. © 2021 Elsevier Inc.

Item Type:	Journal Article
Publication:	Experimental Cell Research
Publisher:	Elsevier Inc.
Additional Information:	Copyright to this article belongs to Elsevier Inc.
Department/Centre:	Division of Biological Sciences > Biochemistry Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	10 Feb 2021 10:56
Last Modified:	10 Feb 2021 10:56
URI:	http://eprints.iisc.ac.in/id/eprint/67858

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