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Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria

Chatterjee, R and Chowdhury, AR and Mukherjee, D and Chakravortty, D (2021) Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria. In: Virulence, 12 (1). pp. 195-216.

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Official URL: https://dx.doi.org/10.1080/21505594.2020.1869441


Lipids are complex organic compounds made up of carbon, oxygen, and hydrogen. These play a diverse and intricate role in cellular processes like membrane trafficking, protein sorting, signal transduction, and bacterial infections. Both Gram-positive bacteria (Staphylococcus sp., Listeria monocytogenes, etc.) and Gram-negative bacteria (Chlamydia sp., Salmonella sp., E. coli, etc.) can hijack the various host-lipids and utilize them structurally as well as functionally to mount a successful infection. The pathogens can deploy with various arsenals to exploit host membrane lipids and lipid-associated receptors as an attachment for toxins� landing or facilitate their entry into the host cellular niche. Bacterial species like Mycobacterium sp. can also modulate the host lipid metabolism to fetch its carbon source from the host. The sequential conversion of host membrane lipids into arachidonic acid and prostaglandin E2 due to increased activity of cPLA-2 and COX-2 upon bacterial infection creates immunosuppressive conditions and facilitates the intracellular growth and proliferation of bacteria. However, lipids� more debatable role is that they can also be a blessing in disguise. Certain host-lipids, especially sphingolipids, have been shown to play a crucial antibacterial role and help the host in combating the infections. This review shed light on the detailed role of host lipids in bacterial infections and the current understanding of the lipid in therapeutics. We have also discussed potential prospects and the need of the hour to help us cope in this race against deadly pathogens and their rapidly evolving stealthy virulence strategies. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Journal Article
Publication: Virulence
Publisher: Bellwether Publishing, Ltd.
Additional Information: Copyright to this article belongs to Bellwether Publishing, Ltd.
Keywords: arachidonic acid; bacterial toxin; lipid; membrane lipid; prostaglandin E2; sphingolipid, bacterial growth; bacterial infection; bacterium identification; CD8+ T lymphocyte; Chlamydia; endocytosis; Gram negative bacterium; Gram positive bacterium; lipid metabolism; lipid raft; Listeria monocytogenes; nonhuman; nutrient; pathogenesis; Review; Salmonella; signal transduction; Staphylococcus
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 02 Feb 2021 11:02
Last Modified: 02 Feb 2021 11:02
URI: http://eprints.iisc.ac.in/id/eprint/67812

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