Synthesis of the C9-C22 fragment of polyene polyol containing macrolactone natural product pentamycin

Bali, AK and Prasad, KR (2020) Synthesis of the C9-C22 fragment of polyene polyol containing macrolactone natural product pentamycin. In: Tetrahedron, 76 (52).

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Abstract

Stereoselective synthesis of the C9-C22 fragment of pentamycin from the bis-Weinreb amide of D-tartaric acid was accomplished in 12 steps (14 yield). Key reactions in the synthesis include Ley's dithiaketalization, Narasaka stereoselective reduction of the β-hydroxy ketone and Wittig reaction with a vinylogous phosphonate. © 2020 Elsevier Ltd

Item Type:	Journal Article
Publication:	Tetrahedron
Publisher:	Elsevier Ltd
Additional Information:	The copyright of this article belongs to Tetrahedron
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	24 Dec 2020 10:35
Last Modified:	24 Dec 2020 10:35
URI:	http://eprints.iisc.ac.in/id/eprint/67478

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