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Self-Assembled Pd12Coordination Cage as Photoregulated Oxidase-Like Nanozyme

Bhattacharyya, S and Ali, SR and Venkateswarulu, M and Howlader, P and Zangrando, E and De, M and Mukherjee, PS (2020) Self-Assembled Pd12Coordination Cage as Photoregulated Oxidase-Like Nanozyme. In: Journal of the American Chemical Society, 142 (44). pp. 18981-18989.

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Official URL: https://dx.doi.org/10.1021/jacs.0c09567


Designing supramolecular architectures with uncommon geometries embedded with functional building units is of immense importance in contemporary research. In this report, we present a new water-soluble Pd12L6 supramolecular coordination nanocage (1) that was synthesized via self-assembly of a tetradentate donor (L) with ditopic acceptor cis-(en)Pd(NO3)2 en = ethylenediamine. Self-assembly of a tetratopic donor with a cis-blocked 90° acceptor commonly produces tri/tetra- or hexagonal barrel-type structures. However, the resulting cage 1 has an uncommon geometry consisting of two triangular cupolas conjoined through an irregular common hexagonal base. Incorporation of the benzothiadiazole unit in the structure helped in the photogeneration of reactive oxygen species (ROS) in water. Many nanomaterials have shown to have the ability to mimic the catalytic activity of natural enzymes (nanozymes). Majority of such nanozymes are water insoluble metal/metal-oxide nanoparticles or extended metal organic frameworks (MOFs)/metal-carbon composites, etc. The present water-soluble Pd12 nanocage 1 has shown excellent oxidase-like activity upon irradiation with white light. The enzymatic activity of 1 is photoregulated which offers other obvious advantages, such as external control of enzymatic activity and noninvasiveness. The oxidase-like activity and exogenous ROS generation have been further exploited in photocatalytic antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) bacterial strain. © 2020 American Chemical Society.

Item Type: Journal Article
Publication: Journal of the American Chemical Society
Publisher: American Chemical Society
Additional Information: The copyright of this article belongs to American Chemical Society
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Division of Chemical Sciences > Organic Chemistry
Date Deposited: 22 Dec 2020 11:57
Last Modified: 22 Dec 2020 11:57
URI: http://eprints.iisc.ac.in/id/eprint/67456

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