BODIPY based red emitters: Synthesis, computational and biological studies

Pandey, V and Raza, MK and Sonowal, M and Gupta, I (2021) BODIPY based red emitters: Synthesis, computational and biological studies. In: Bioorganic Chemistry, 106 .

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Abstract

Donor-Acceptor type BODIPYs with strong absorption and fluorescence in the red region (550�800 nm) are reported. The aromatic groups like N-butylcarbazole/ N-butylphenothiazine/ benzothiadiazole were attached to the C-8 position of the BODIPY core with furan or thiophene spacers. TD-DFT studies indicated significant charge distribution between C-8 aromatic heterocycles and BODIPY core in all the molecules. The in-vitro studies of the N-butylcarbazole substituted BODIPYs indicated significant localization in the endoplasmic reticulum and lysosomes of the cancer cells. The BODIPYs showed decent cytotoxicity after 48 h incubation period (14.9 to 31.8 μM) in HeLa and A549 cancer cells, indicating their potential application as theranostic agents. © 2020 Elsevier Inc.

Item Type:	Journal Article
Publication:	Bioorganic Chemistry
Publisher:	Academic Press Inc.
Additional Information:	The copyright of this article belongs to Academic Press Inc.
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	12 Jan 2021 11:03
Last Modified:	12 Jan 2021 11:03
URI:	http://eprints.iisc.ac.in/id/eprint/67413

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