Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4-Oxadiazole as Anticancer Agents

Gopinatha, Vindya K and Ray, U and Mantelingu, K and Raghavan, SC and Rangappa, KS (2020) Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4-Oxadiazole as Anticancer Agents. In: Russian Journal of Bioorganic Chemistry, 46 (5). pp. 837-844.

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Abstract

Abstract: A series of theophylline methyl 1,3,4-oxadiazole small molecules were obtained via cyclization of theophylline-7-acetohydrazide with different benzoic acids. The compounds (IVa�j) were synthesized and characterized by using conventional methods. The new compounds obtained were evaluated for their cytotoxic effect in three different cancer lines, the activity obtained varies depending upon the structure of a molecule. The compound (IVb) and (IVf) showed promising effect than other compounds of the series. Thus, these two derivatives have the potential for developing as anticancer agents. © 2020, Pleiades Publishing, Ltd.

Item Type:	Journal Article
Publication:	Russian Journal of Bioorganic Chemistry
Publisher:	Pleiades journals
Additional Information:	The copyright of this article belongs to Pleiades journals
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	04 Feb 2021 06:06
Last Modified:	04 Feb 2021 06:06
URI:	http://eprints.iisc.ac.in/id/eprint/67390

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