Synthesis of the macrolactone core of the revised structure of palmerolide C

Vaithegi, K and Pawar, AB and Prasad, KR (2021) Synthesis of the macrolactone core of the revised structure of palmerolide C. In: Tetrahedron . (In Press)

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Abstract

Synthetic efforts towards the total synthesis of the revised structure of marine macrolide palmerolide C is reported. Synthesis of the triol unit present in the C8,C9, C10 positions was achieved from D-ribose while Johnson orthoester rearrangement and a Wittig reaction were used to construct the C1�C7 component of the macrolactone. The key macrolactone unit was assembled using intermolecular Heck coupling reaction and Yamaguchi lactonization. © 2020 Elsevier Ltd

Item Type:	Journal Article
Publication:	Tetrahedron
Publisher:	Elsevier Ltd
Additional Information:	Copyright to this artilce belongs to Elsevier Ltd
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	22 Dec 2020 11:09
Last Modified:	22 Dec 2020 11:09
URI:	http://eprints.iisc.ac.in/id/eprint/67224

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