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Influence of Oxidation Degree of Graphene Oxide on Its Nuclear Relaxivity and Contrast in MRI

Mohanta, Z and Gaonkar, SK and Kumar, M and Saini, J and Tiwari, V and Srivastava, C and Atreya, HS (2020) Influence of Oxidation Degree of Graphene Oxide on Its Nuclear Relaxivity and Contrast in MRI. In: ACS Omega . (In Press)

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Official URL: https://dx.doi.org/10.1021/acsomega.0c02220


Graphene oxide (GO) serves as a versatile platform for various applications, with the oxygen content of GO playing an important role in governing its properties. In the present study, different GO types covering a wide range of oxidation degree were prepared using our newly developed two-step method involving ball milling of graphite followed by its oxidation to GO. In addition to the variations in their physicochemical properties, the different GO types exhibited differences in proton relaxivity due to their paramagnetic nature. Nuclear magnetic resonance spectroscopy studies showed that the degree of oxidation of GO perturbs its nuclear relaxation properties and, together with intercalated Mn2+ ions, provides large contrast variation in magnetic resonance imaging (MRI). The study for the first time reveals that the surface chemistry of GO affects its relaxivity and opens up new avenues for developing tunable GO-based contrast agents in magnetic resonance imaging for diagnostics and therapies. © Copyright © 2020 American Chemical Society.

Item Type: Journal Article
Publication: ACS Omega
Publisher: American Chemical Society
Additional Information: copyright for this article belongs to American Chemical Society
Department/Centre: Autonomous Societies / Centres > Centre for Brain Research
Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility)
Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 28 Oct 2020 06:53
Last Modified: 28 Oct 2020 06:53
URI: http://eprints.iisc.ac.in/id/eprint/67012

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