Mathematical modeling of plasticity and heterogeneity in EMT

Tripathi, S and Xing, J and Levine, H and Jolly, MK (2020) Mathematical modeling of plasticity and heterogeneity in EMT. [Book Chapter]

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Abstract

The epithelial-mesenchymal transition (EMT) and the corresponding reverse process, mesenchymal-epithelial transition (MET), are dynamic and reversible cellular programs orchestrated by many changes at both biochemical and morphological levels. A recent surge in identifying the molecular mechanisms underlying EMT/MET has led to the development of various mathematical models that have contributed to our improved understanding of dynamics at single-cell and population levels: (a) multi-stability�how many phenotypes can cells attain during an EMT/MET?, (b) reversibility/irreversibility�what time and/or concentration of an EMT inducer marks the �tipping point� when cells induced to undergo EMT cannot revert?, (c) symmetry in EMT/MET�do cells take the same path when reverting as they took during the induction of EMT?, and (d) non-cell autonomous mechanisms�how does a cell undergoing EMT alter the tendency of its neighbors to undergo EMT? These dynamical traits may facilitate a heterogenous response within a cell population undergoing EMT/MET. Here, we present a few examples of designing different mathematical models that can contribute to decoding EMT/MET dynamics. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Item Type:	Book Chapter
Publication:	Methods in Molecular Biology
Series.:	Methods in Molecular Biology
Publisher:	Humana Press Inc.
Additional Information:	Copyright to this article belongs to Humana Press Inc.
Keywords:	article; epithelial mesenchymal transition
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	27 Nov 2020 10:34
Last Modified:	27 Nov 2020 10:34
URI:	http://eprints.iisc.ac.in/id/eprint/66798

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