Emerging potential of niosomes in ocular delivery

Verma, A and Tiwari, A and Saraf, S and Panda, PK and Jain, A and Jain, SK (2020) Emerging potential of niosomes in ocular delivery. In: Expert Opinion on Drug Delivery . (In Press)

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Abstract

Introduction: Niosomes have recently grabbed attention as one of the best tools for various site-specific drug delivery systems, including ophthalmic drug delivery. Surfactants (nonionic; tweens and spans) of different HLB values and cholesterol are the fundamental components for these formulations. It is an alternative controlled ocular drug delivery system to liposomes to overcome the problems associated with sterilization, large-scale production, and stability. It also enhances the adhesion or retention ability of drug at the ocular site. Hydrophilic or lipophilic or amphoteric drugs can be easily encapsulated in niosomes. Besides, niosomes are a leading vesicular system compatible with most of the drugs for site-specific delivery. Areas covered: This article reveals challenges and barriers for ocular drug delivery, various transporters and receptors present in the ocular region for the transportation of therapeutics as well as nutrients, and various method of preparations, loading methods and application potential of niosomes in ocular drug delivery. Expert opinion: Niosomes, a vesicular system offers numerous advantages and applicability because of its good stability, non-immunogenicity, permeation potential, and controlled release ability etc. This drug delivery system has been efficiently used in the treatment of many ocular diseases. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Item Type:	Journal Article
Publication:	Expert Opinion on Drug Delivery
Publisher:	Taylor and Francis Ltd.
Additional Information:	Copyright to this article belongs to Taylor and Francis Ltd.
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	15 Dec 2020 06:37
Last Modified:	15 Dec 2020 06:37
URI:	http://eprints.iisc.ac.in/id/eprint/66781

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