Novel synthetic aromatic thiourea derivatives and investigations on their cytotoxic potential efficacy

Ray, U and John, F and Pooppadi, S and George, J and Sharma, S and Raghavan, SC (2020) Novel synthetic aromatic thiourea derivatives and investigations on their cytotoxic potential efficacy. In: Journal of Heterocyclic Chemistry .

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Abstract

Aromatic thiourea derivatives were synthesized by standard reactions from isothiocyanates in high yield. An efficient one-pot synthesis of primary amine with carbon disulfide involving the intermediate dithiocarbamate conversion using T3P (propane phosphonic anhydride) to isothiocyanate is reported. Newly synthesized compounds showed excellent luminescence property. Cytotoxic investigation with different human cancer cell lines showed IC50 values varying from of 17 to 40 μM for N-phenethyl-3,4-dihydroisoquinoline-2(1H)-carbothioamide (SCR172) among other molecules. Increase in Sub G1 population and increased depolarisation of mitochondria were evident in cells treated with SCR172, suggesting its role as a cancer therapeutic agent. This provides a lead structure for further synthetic modifications. © 2020 Wiley Periodicals LLC.

Item Type:	Journal Article
Publication:	Journal of Heterocyclic Chemistry
Publisher:	Hetero Corporation
Additional Information:	The copyright of this article belongs to Hetero Corporation
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	04 Nov 2020 08:46
Last Modified:	04 Nov 2020 08:46
URI:	http://eprints.iisc.ac.in/id/eprint/66700

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