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Poly(Ethylene glycol) functionalized graphene oxide in tissue engineering: A review on recent advances

Ghosh, S and Chatterjee, K (2020) Poly(Ethylene glycol) functionalized graphene oxide in tissue engineering: A review on recent advances. In: International Journal of Nanomedicine, 15 . pp. 5991-6006.

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Official URL: https://dx.doi.org/10.2147/IJN.S249717


Owing to the unique physical, chemical, mechanical and electrical properties, graphene and its derivatives have been extensively researched for diverse biomedical applications including in tissue engineering since the past decade. Tunable chemical functional-ities of graphene oxide (GO), a graphene derivative, allow easy surface functionalization. Functionalization of GO with poly(ethylene glycol) (PEG) (PEG-GO) has received signifi-cant attention as it offers superior solubility, stability, and biocompatibility. Besides being an attractive candidate for drug delivery, PEG-GO can aid in the attachment, proliferation, and differentiation of stem cells, thereby augmenting tissue engineering. PEG-GO has shown excellent antibacterial efficacy, which could be an added advantage to minimize implant-associated infections. This review describes the synthesis techniques, properties, and biological potential of PEG-GO towards mammalian and bacterial cells. Studies wherein these nanomaterials have been explored for engineering various tissues are reviewed along with future opportunities in this field. © 2020 Ghosh and Chatterjee.

Item Type: Journal Article
Publication: International Journal of Nanomedicine
Publisher: Dove Medical Press Ltd.
Additional Information: The copyright of this article belongs to Dove Medical Press Ltd.
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 01 Jan 2021 11:21
Last Modified: 01 Jan 2021 11:21
URI: http://eprints.iisc.ac.in/id/eprint/66637

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