Iodine-Promoted One-Pot Multicomponent Chemoselective Reaction for C-C/C-N and C-C/C-S Bond Formation Using Thiols

Panigrahi, A and Muniraj, N and Prabhu, KR (2020) Iodine-Promoted One-Pot Multicomponent Chemoselective Reaction for C-C/C-N and C-C/C-S Bond Formation Using Thiols. In: European Journal of Organic Chemistry .

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Abstract

A simple approach for a C�N bond-forming reaction is developed using a multicomponent strategy. Iodine promoted multicomponent reaction of heterocyclic thiols, aromatic aldehydes, and trimethoxybenzene proceeds at the ambient temperature in TFE in a short period. The reaction is also compatible with aromatic thiols leading to C�S bond formation. Heterocyclic thiols undergo a chemoselective reaction affording the corresponding C�N products over C�S products. To the best of our knowledge, this is the first report for C�N bond formation using heterocyclic thiols, trimethoxybenzene, and aromatic aldehydes, where the solvent is playing a significant role and iodine is acting as a promoter. © 2020 Wiley-VCH GmbH

Item Type:	Journal Article
Publication:	European Journal of Organic Chemistry
Publisher:	Wiley-VCH Verlag
Additional Information:	The copyright of this article belongs to Wiley-VCH Verlag
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	18 Sep 2020 10:20
Last Modified:	18 Sep 2020 10:20
URI:	http://eprints.iisc.ac.in/id/eprint/66495

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