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A decade in unravelling the etiology of gastric carcinogenesis in Kashmir, India � A high risk region

Nissar, B and Shah, IA and ul Afshan, F and Ganai, BA (2020) A decade in unravelling the etiology of gastric carcinogenesis in Kashmir, India � A high risk region. In: Gene Reports, 21 .

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Official URL: https://dx.doi.org/10.1016/j.genrep.2020.100832


Gastric cancer is one of the leading causes of cancer-related deaths globally. Although, understanding the molecular mechanisms leading to gastric carcinogenesis has gained much importance in the last few decades, yet biomarkers for early detection are not available so far. Kashmir valley- India, represents a high-risk cancer region, has unique dietary and sociocultural practices, which makes it an intriguing region for studying the etiology of gastric cancer. Although several studies have been carried out in Kashmir in the recent past to understand the role of genetic and/or environmental factors in the development of the disease, the complete etiology, and causes of the high incidence of this disease, yet remains unclear. This review summarises the currently available results on various dietary, environmental factors, and genetic factors studied in the Kashmiri population and their relevance with the global understanding of the disease. © 2020 Elsevier Inc.

Item Type: Journal Article
Publication: Gene Reports
Publisher: Elsevier Inc
Additional Information: The copyright of this article belongs to Elsevier Inc
Keywords: 8 oxoguanine dna glycosylase i; caspase 8; cytokine; DNA; DNA glycosyltransferase; DNA repair protein XRCC1; FLICE inhibitory protein; interleukin 10; interleukin 1beta; matrilysin; MutL protein homolog 1; protein p53; unclassified drug; xenobiotic agent; xeroderma pigmentosum group D protein; XRCC3 protein, cancer growth; cancer risk; cancer staging; chromosomal instability; CpG island; diet; diffuse gastric carcinoma; DNA repair; early cancer diagnosis; environmental factor; gene mutation; Helicobacter pylori; heredity; high risk population; human; Jammu and Kashmir; Kashmiri (people); microsatellite instability; molecular pathology; phenotype; priority journal; Review; social class; stomach cancer; stomach carcinogenesis; stomach carcinoma
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 04 Sep 2020 10:03
Last Modified: 04 Sep 2020 10:03
URI: http://eprints.iisc.ac.in/id/eprint/66472

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