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Nanoceria-Based Phospholipase-Mimetic Cell Membrane Disruptive Antibiofilm Agents

Khulbe, K and Karmakar, K and Ghosh, S and Chandra, K and Chakravortty, D and Mugesh, G (2020) Nanoceria-Based Phospholipase-Mimetic Cell Membrane Disruptive Antibiofilm Agents. In: ACS Applied Bio Materials, 3 (7). pp. 4316-4328.

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Official URL: https://dx.doi.org/10.1021/acsabm.0c00363


Continuous mounting of antibiotic resistance due to the narrow range of mechanisms targeted poses tremendous threat to global health. Highly resistant pathogenic bacteria dwelling in the biofilm mode on the surface of medical devices has increased the susceptibility of chronic as well as healthcare-associated infections. Lantipeptides have shown promising membrane disruption of Gram-positive bacteria, leading to programmed cell death, but they are impermeable and hence ineffective to the outer cell membrane of Gram-negative bacteria. Herein, we report for the first time that a polymer-coated nanoceria (PAA-Cnp) having phospholipase-mimetic activity can target the cell membrane of both Gram-negative and Gram-positive bacteria. The nanozyme shows promising membrane disruption-based bactericidal activity against a broad spectrum of pathogenic as well as biofilm-encased bacteria. The unprecedented nanozyme-based strategy described in this paper is useful in preventing biofilm formation on medical devices such as urinary catheters. © 2020 American Chemical Society.

Item Type: Journal Article
Publication: ACS Applied Bio Materials
Publisher: American Chemical Society
Additional Information: The copyright of this article belongs to American Chemical Society
Keywords: Biofilms; Cell death; Health risks; Membranes, Antibiotic resistance; Bactericidal activity; Biofilm formation; Gram-negative bacteria; Gram-positive bacterium; Membrane disruption; Pathogenic bacterium; Programmed cell deaths, Bacteria
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 25 Aug 2020 11:06
Last Modified: 25 Aug 2020 11:06
URI: http://eprints.iisc.ac.in/id/eprint/66365

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