Application of Cp2TiCl-Promoted Radical-Induced Cyclization: An Expeditious Access to a-Annelated Indoles

Khan, HPA and Chakraborty, TK (2020) Application of Cp2TiCl-Promoted Radical-Induced Cyclization: An Expeditious Access to a-Annelated Indoles. In: Journal of Organic Chemistry, 85 (12). pp. 8000-8012.

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Abstract

An efficient and novel route for assembling pyrrolo/piperido1,2-aindoles is portrayed involving a radical-mediated reductive epoxide opening reaction of N-tethered epoxy-indoles that trigger facile intramolecular cyclization followed by an oxidative quenching step. Capitalizing on the operational simplicity of the method involving just two steps and use of an efficient C-C bond-forming reaction, this radical-based protocol enables the modular assembly of an important class of N-fused indole derivatives with versatile functional and structural diversity. Copyright © 2020 American Chemical Society.

Item Type:	Journal Article
Publication:	Journal of Organic Chemistry
Publisher:	American Chemical Society
Additional Information:	Copy right for this article belongs to American Chemical Society.
Keywords:	Purification,Column chromatography,Silica,Indoles,Gels
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	13 Mar 2021 06:43
Last Modified:	13 Mar 2021 06:43
URI:	http://eprints.iisc.ac.in/id/eprint/66168

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