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SRSF3: Newly discovered functions and roles in human health and diseases

More, DA and Kumar, A (2020) SRSF3: Newly discovered functions and roles in human health and diseases. In: European Journal of Cell Biology, 99 (6).

EUR_JOU_CEL_BIO_99_6_2020.pdf - Published Version

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Official URL: https://dx.doi.org/10.1016/j.ejcb.2020.151099


The serine/arginine rich proteins (SR proteins) are members of a family of RNA binding proteins involved in regulating various features of RNA metabolism, including pre-mRNA constitutive and alternative splicing. In humans, a total of 12 SR splicing factors (SRSFs) namely SRSF1-SRSF12 have been reported. SRSF3, the smallest member of the SR family and the focus of this review, regulates critical steps in mRNA metabolism and has been shown to have mRNA-independent functions as well. Recent studies on SRSF3 have uncovered its role in a wide array of complex biological processes. We have also reviewed the involvement of SRSF3 in disease conditions like cancer, ageing, neurological and cardiac disorders. Finally, we have discussed in detail the autoregulation of SRSF3 and its implications in cancer and commented on the potential of SRSF3 as a therapeutic target, especially in the context of cancer. © 2020

Item Type: Journal Article
Publication: European Journal of Cell Biology
Publisher: Elsevier GmbH
Additional Information: Copy right for this article belongs to Elsevier GmbH
Keywords: Splicing factors SR proteins SRSF SRSF3 Cancer Disease
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 05 Jan 2021 11:50
Last Modified: 05 Jan 2021 11:50
URI: http://eprints.iisc.ac.in/id/eprint/65966

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