ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

What do we know about DNA mechanics so far?

Aggarwal, A and Naskar, S and Sahoo, AK and Mogurampelly, S and Garai, A and Maiti, PK (2020) What do we know about DNA mechanics so far? In: Current Opinion in Structural Biology, 64 . pp. 42-50.

cur_opi_str_bio_64_42-50_2020.pdf - Published Version

Download (2MB) | Preview
Official URL: https://doi.org/10.1016/j.sbi.2020.05.010


The DNA molecule, apart from carrying the genetic information, plays a crucial role in a variety of biological processes and finds applications in drug design, nanotechnology and nanoelectronics. The molecule undergoes significant structural transitions under the influence of forces due to physiological and non-physiological environments. Here, we summarize the insights gained from simulations and single-molecule experiments on the structural transitions and mechanics of DNA under force, as well as its elastic properties, in various environmental conditions, and discuss appealing future directions. © 2020 Elsevier Ltd

Item Type: Journal Article
Publication: Current Opinion in Structural Biology
Publisher: Elsevier Ltd
Additional Information: The copyright for this article belongs to authors
Keywords: DNA; double stranded DNA, binding affinity; chromosome; complex formation; conformational transition; DNA mechanics; DNA packaging; DNA repair; DNA replication; DNA sequence; DNA structure; epigenetics; gene expression regulation; genetic transcription; molecular genetic phenomena and functions; nanobiotechnology; phase transition; priority journal; protein DNA binding; Review; structure analysis
Department/Centre: Division of Physical & Mathematical Sciences > Physics
Date Deposited: 16 Aug 2021 11:00
Last Modified: 16 Aug 2021 11:00
URI: http://eprints.iisc.ac.in/id/eprint/65959

Actions (login required)

View Item View Item