Aggarwal, A and Naskar, S and Sahoo, AK and Mogurampelly, S and Garai, A and Maiti, PK (2020) What do we know about DNA mechanics so far? In: Current Opinion in Structural Biology, 64 . pp. 42-50.
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Abstract
The DNA molecule, apart from carrying the genetic information, plays a crucial role in a variety of biological processes and finds applications in drug design, nanotechnology and nanoelectronics. The molecule undergoes significant structural transitions under the influence of forces due to physiological and non-physiological environments. Here, we summarize the insights gained from simulations and single-molecule experiments on the structural transitions and mechanics of DNA under force, as well as its elastic properties, in various environmental conditions, and discuss appealing future directions. © 2020 Elsevier Ltd
| Item Type: | Journal Article |
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| Publication: | Current Opinion in Structural Biology |
| Publisher: | Elsevier Ltd |
| Additional Information: | The copyright for this article belongs to authors |
| Keywords: | DNA; double stranded DNA, binding affinity; chromosome; complex formation; conformational transition; DNA mechanics; DNA packaging; DNA repair; DNA replication; DNA sequence; DNA structure; epigenetics; gene expression regulation; genetic transcription; molecular genetic phenomena and functions; nanobiotechnology; phase transition; priority journal; protein DNA binding; Review; structure analysis |
| Department/Centre: | Division of Physical & Mathematical Sciences > Physics |
| Date Deposited: | 16 Aug 2021 11:00 |
| Last Modified: | 16 Aug 2021 11:00 |
| URI: | http://eprints.iisc.ac.in/id/eprint/65959 |
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