microRNAs: New-Age Panacea in Cancer Therapeutics

Sarkar, N and Kumar, A (2020) microRNAs: New-Age Panacea in Cancer Therapeutics. In: Indian Journal of Surgical Oncology .

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Abstract

MicroRNAs (miRNAs) are small (~ 18�25 nucleotides in length), endogenous, non-coding RNAs, which regulate gene expression. Numerous studies have demonstrated the dysregulation of miRNA expression in human cancers through various mechanisms, which include genetic alteration of miRNA genes, abnormal transcriptional control of miRNAs, anomalous epigenetic changes, and defective miRNA biogenesis machinery. They may function as either oncomiRs or tumor suppressor miRNAs in a tissue or cell-specific manner. The dysregulated miRNAs are known to affect the hallmarks of cancer, and some of these miRNAs have shown therapeutic promise in pre-clinical and clinical studies. Here, we briefly touch upon various aspects of miRNA biology with a particular focus on their roles in cancer. © 2020, Indian Association of Surgical Oncology.

Item Type:	Journal Article
Publication:	Indian Journal of Surgical Oncology
Publisher:	Springer
Additional Information:	Copy right for this article belongs to Springer
Keywords:	MiRNA . Dysregulation . Cancer . Clinical trial
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	21 Oct 2020 06:42
Last Modified:	21 Oct 2020 06:42
URI:	http://eprints.iisc.ac.in/id/eprint/65762

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