Ruthenium N-Heterocyclic Carbene Complexes for Chemoselective Reduction of Imines and Reductive Amination of Aldehydes and Ketones

Kathuria, L and Samuelson, AG (2020) Ruthenium N-Heterocyclic Carbene Complexes for Chemoselective Reduction of Imines and Reductive Amination of Aldehydes and Ketones. In: European Journal of Inorganic Chemistry .

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Abstract

Chemoselective reduction of imines to secondary amines is catalyzed efficiently by tethered and untethered, half-sandwich ruthenium N-heterocyclic carbene (NHC) complexes at room temperature. The untethered Ru-NHC complexes are more efficient as catalysts for the reduction of aldimines and ketimines than the tethered complexes. Using the best untethered complex as a catalyst, electronic and steric demands on the reaction was probed using a series of imines. Chemoselectivity of the catalyst towards imine reduction was tested by performing inter and intramolecular competitive reactions in a variety of ways. The catalyst exhibits a very high TON and TOF under anaerobic conditions. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Item Type:	Journal Article
Publication:	European Journal of Inorganic Chemistry
Publisher:	Wiley-VCH Verlag
Additional Information:	cited By 0
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	22 Sep 2021 10:01
Last Modified:	22 Sep 2021 10:01
URI:	http://eprints.iisc.ac.in/id/eprint/65761

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