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Cellular Plasticity in Matrix-attached and -Detached Cells: Implications in Metastasis

Ranganathan, S and Kumar, S and Mohanty, SS and Jolly, MK and Rangarajan, A (2020) Cellular Plasticity in Matrix-attached and -Detached Cells: Implications in Metastasis. In: Journal of the Indian Institute of Science, 100 (3). pp. 525-536.

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Official URL: https://dx.doi.org/10.1007/s41745-020-00179-0


The ability of cells to assume different phenotypes without changing their genotypeGenotype: The complete genetic constitution of an organism. is referred to as cellular plasticity. It is increasingly being recognized as a fundamental and essential property of cancer cells, which enables their adaptation to the changing environmental conditions, imposed by both disease progression and therapeutic intervention. Epithelial�mesenchymal transition (EMT) is a classical well-studied example of cellular plasticity during cancer progression that aids cancer spread by metastasis. A closely associated phenomenon that entails metastatic progression is the detachment of cancer cells from the extracellular matrix (ECM) at the primary tumor site, their passage and survival in the circulation in an anchorage-independent form, and subsequent re-attachment at a distant site to establish new tumor growth. In this review, we discuss molecular and metabolic plasticity in matrix-attached and -detached states of cancer cells that aid in metastatic cancer progression. Further, cellular plasticity enables cancer cells within a population to assume different phenotypic states, thus leading to cancer heterogeneity�an emerging evil that needs to be tackled for overcoming therapy failure and achieving better treatment outcomes. © 2020, Indian Institute of Science.

Item Type: Journal Article
Publication: Journal of the Indian Institute of Science
Publisher: Springer
Additional Information: Copy right for this article belongs to Springer
Keywords: Cytology; Diseases; Pathology; Tumors, Cancer heterogeneities; Cancer progression; Disease progression; Environmental conditions; Extracellular matrices; Metastatic cancers; Therapeutic intervention; Treatment outcomes, Cells
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 21 Oct 2020 07:05
Last Modified: 21 Oct 2020 07:05
URI: http://eprints.iisc.ac.in/id/eprint/65756

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