Parthasarathy, R and Chandrika, M and Yashavantha Rao, HC and Kamalraj, S and Jayabaskaran, C and Pugazhendhi, A (2020) Molecular profiling of marine endophytic fungi from green algae: Assessment of antibacterial and anticancer activities. In: Process Biochemistry, 96 . pp. 11-20.
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Abstract
Bioactive natural metabolites, especially from the marine endophytic fungi, are largely unexplored. Endophytic fungi are being increasingly recognized as a group of organisms that produce novel metabolites of industrial importance. This study investigated the anticancer and antibacterial potential of the marine algal endophyte, Penicillium chrysogenum. The different organic solvent extracts of the endophytic fungi grown on different growth medium were analyzed for anticancer and antibacterial activities. The highest inhibitory activity was observed for the ethyl acetate (EA) extract of the culture filtrate grown in potato dextrose broth (PDB) for 21 days, against the tested human breast cancer cell (MCF-7) line. Similarly, the PDB-EA extract showed an appreciable activity against the human pathogens. The biochemical analysis of the Cha EA metabolites revealed terpenoids, steroids, phenolics and flavones. Gas Chromatography (GCsbndMS) data revealed several bioactive compounds such as anthraquinone and cinnamic acid. The Cha EA extract induced membrane damage and thus, apoptosis in MCF-7cells. The secondary metabolites produced by these marine endophytic fungi have contributed to considerable anticancer and antimicrobial activities and hence, this study is an evidence of potential sources of antimicrobial and anticancer compounds from Penicillium chrysogenum. © 2020 Elsevier Ltd
Item Type: | Journal Article |
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Publication: | Process Biochemistry |
Publisher: | Elsevier Ltd |
Additional Information: | Copy right for this article belongs to Elsevier Ltd |
Keywords: | Algae; Biomolecules; Cell death; Gas chromatography; Ketones; Lipids; Metabolites; Microorganisms, Anti-bacterial activity; Anti-microbial activity; Anticancer activities; Anticancer compounds; Biochemical analysis; Human breast cancer cells; Penicillium chrysogenum; Secondary metabolites, Fungi |
Department/Centre: | Division of Biological Sciences > Biochemistry |
Date Deposited: | 04 Jan 2021 06:11 |
Last Modified: | 04 Jan 2021 06:11 |
URI: | http://eprints.iisc.ac.in/id/eprint/65700 |
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