Synthesis and Biological Studies of Dodecameric Cationic Antimicrobial Peptides Containing Tetrahydrofuran Amino Acids

Ghosh, U and Soni, I and Kaul, G and Trivedi, P and Chaturvedi, V and Chopra, S and Kanti Chakraborty, T (2020) Synthesis and Biological Studies of Dodecameric Cationic Antimicrobial Peptides Containing Tetrahydrofuran Amino Acids. In: ChemBioChem, 21 (17). pp. 2518-2526.

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Abstract

We report here a concise route to synthesize various stereoisomers of tetrahydrofuran amino acids (TAAs) and the synthesis of TAA-containing linear cationic dodecapeptides. Some of these linear peptides show slightly better antimicrobial activities than their tetra- and octameric congeners, but no activity against Mycobacterium tuberculosis, for which octapeptides exhibited by far the best results; this implies that antibacterial activity is dependent on the length of these linear peptides. All the dodecapeptides described here were found to be toxic in nature against Vero cells. The study helps to delineate the optimal length of this series of linear peptides and select potential leads in the development of novel cationic peptide-based antibiotics. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Item Type:	Journal Article
Publication:	ChemBioChem
Publisher:	Wiley-VCH Verlag
Additional Information:	The copyright of this article belongs to Wiley-VCH Verlag
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	05 Apr 2021 07:20
Last Modified:	05 Apr 2021 07:20
URI:	http://eprints.iisc.ac.in/id/eprint/65528

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