Yashavantha Rao, HC and Jayabaskaran, C (2020) The emergence of a novel coronavirus (SARS-CoV-2) disease and their neuroinvasive propensity may affect in COVID-19 patients. In: Journal of Medical Virology, 92 (7). pp. 786-790.
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Abstract
An outbreak of a novel coronavirus (SARS-CoV-2) infection has recently emerged and rapidly spreading in humans causing a significant threat to international health and the economy. Rapid assessment and warning are crucial for an outbreak analysis in response to serious public health. SARS-CoV-2 shares highly homological sequences with SARS-CoVs causing highly lethal pneumonia with respiratory distress and clinical symptoms similar to those reported for SARS-CoV and MERS-CoV infections. Notably, some COVID-19 patients also expressed neurologic signs like nausea, headache, and vomiting. Several studies have reported that coronaviruses are not only causing respiratory illness but also invade the central nervous system through a synapse-connected route. SARS-CoV infections are reported in both patients and experimental animals' brains. Interestingly, some COVID-19 patients have shown the presence of SARS-CoV-2 virus in their cerebrospinal fluid. Considering the similarities between SARS-CoV and SARS-CoV-2 in various aspects, it remains to clarify whether the potent invasion of SARS-CoV-2 may affect in COVID-19 patients. All these indicate that more detailed criteria are needed for the treatment and the prevention of SARS-CoV-2 infected patients. In the absence of potential interventions for COVID-19, there is an urgent need for an alternative strategy to control the spread of this disease. © 2020 Wiley Periodicals, Inc.
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Medical Virology |
| Publisher: | John Wiley and Sons Inc. |
| Additional Information: | Copy right for this article belongs to John Wiley and Sons Inc. |
| Keywords: | central nervous system, coronavirus, COVID‐19, MERS, neuroinvasive, SARS |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 14 Oct 2020 09:30 |
| Last Modified: | 14 Oct 2020 09:30 |
| URI: | http://eprints.iisc.ac.in/id/eprint/65367 |
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