Diverse roles of nucleoside diphosphate kinase in genome stability and growth fitness

Kapoor, I and Varshney, U (2020) Diverse roles of nucleoside diphosphate kinase in genome stability and growth fitness. In: Current Genetics, 66 (4). pp. 671-682.

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Abstract

Nucleoside diphosphate kinase (NDK), a ubiquitous enzyme, catalyses reversible transfer of the γ phosphate from nucleoside triphosphates to nucleoside diphosphates and functions to maintain the pools of ribonucleotides and deoxyribonucleotides in the cell. As even a minor imbalance in the nucleotide pools can be mutagenic, NDK plays an antimutator role in maintaining genome integrity. However, the mechanism of the antimutator roles of NDK is not completely understood. In addition, NDKs play important roles in the host�pathogen interactions, metastasis, gene regulation, and various cellular metabolic processes. To add to these diverse roles of NDK in cells, a recent study now reveals that NDK may even confer mutator phenotypes to the cell by acting on the damaged deoxyribonucleoside diphosphates that may be formed during the oxidative stress. In this review, we discuss the roles of NDK in homeostasis of the nucleotide pools and genome integrity, and its possible implications in conferring growth/survival fitness to the organisms in the changing environmental niches. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.

Item Type:	Journal Article
Publication:	Current Genetics
Publisher:	Springer
Additional Information:	Copy right for this article belongs to Springer
Keywords:	s 8-Oxo-dGTP (8-O-dGTP) · Adenylate monophosphate kinase (AMK) · Nucleoside diphosphate kinase (NDK) · Nucleotide pool · Mutation rate · Mutation frequency
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	07 Oct 2020 06:13
Last Modified:	07 Oct 2020 06:13
URI:	http://eprints.iisc.ac.in/id/eprint/65184

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