Synthesis of crystalline zinc hydroxystannate and its thermally driven amorphization and recrystallization into zinc orthostannate and their phase-dependent cytotoxicity evaluation

Dillip, GR and Nagajyothi, PC and Ramaraghavulu, R and Banerjee, AN and Reddy, BV and Joo, SW (2020) Synthesis of crystalline zinc hydroxystannate and its thermally driven amorphization and recrystallization into zinc orthostannate and their phase-dependent cytotoxicity evaluation. In: Materials Chemistry and Physics, 248 .

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Abstract

Engineered metal-oxide nanoparticles have greatly been used in various bio-applications, but their physicochemical properties change dramatically within a bio-system. Therefore, the development of new metal-oxide nanoparticles and proper understanding of their toxicity profile in bio-environment are very important for advancement of cancer-related diagnostic and therapeutic approaches. Nanostructured wide-bandgap semiconductors ZnSn(OH)6 and Zn2SnO4 are fabricated by one-pot hydrothermal synthesis and tested for the first time in anti-cancer treatments. The crystalline zinc-hydroxystannate is converted by high-temperature annealing into amorphous and then crystalline zinc-orthostannate, as confirmed by Rietveld refinement analyses. A dose-dependent cytotoxicity is observed when human cervical carcinoma cell lines are exposed to these nanomaterials, mainly due to the elevation of intracellular reactive-oxygen-species levels in the treated cells, which leads to oxidative stress and cell damage. The crystalline phases of the nanomaterials reveal better cell-killing efficacy due to the overlap of the conduction-band energy levels with the cellular redox potential, leading to favorable electron transfer from the biological redox couples to the conduction-band of the semiconductor nanoparticles, thus producing more reactive-oxygen-species for cell damage. Importantly, this higher reactive-oxygen-species production by the crystalline samples significantly reduces cancer cell migration and proliferation and decreases metastasis, which remains an unmet challenge in cancer therapy.

Item Type:	Journal Article
Publication:	Materials Chemistry and Physics
Publisher:	ELSEVIER SCIENCE SA
Additional Information:	The copyright of this article belongs to ELSEVIER SCIENCE SA
Keywords:	Amorphization; Cell culture; Cells; Conduction bands; Diseases; Hydrothermal synthesis; Metal nanoparticles; Metals; Nanostructured materials; Oxygen; Pathology; Physicochemical properties; Reactive oxygen species; Redox reactions; Rietveld refinement; Semiconducting zinc compounds; Tin compounds; Wide band gap semiconductors; X ray photoelectron spectroscopy; Zinc, Cellular redox; Conduction band energy levels; High-temperature annealing; One-pot hydrothermal synthesis; Reduced metastasis; Ros generations; Semiconductor nanoparticles; Zn2SnO4, Semiconducting tin compounds
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	10 Jul 2020 10:50
Last Modified:	10 Jul 2020 10:50
URI:	http://eprints.iisc.ac.in/id/eprint/65107

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