ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging

Yang, H and Jüstel, D and Prakash, J and Karlas, A and Helfen, A and Masthoff, M and Wildgruber, M and Ntziachristos, V (2020) Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging. In: Photoacoustics, 19 .

pho_19_2020.pdf - Published Version

Download (10MB) | Preview
Official URL: https://doi.org/10.1016/j.pacs.2020.100172


Using the same ultrasound detector, hybrid optoacoustic-ultrasound (OPUS) imaging provides concurrent scans of tissue slices or volumes and visualizes complementary sound- and light-based contrast at similar resolutions. In addition to the benefit of hybrid contrast, spatial co-registration enables images from one modality to be employed as prior information for improving an aspect of the performance of the other modality. We consider herein a handheld OPUS system and utilize structural information from ultrasound images to guide regional Laplacian regularization-based reconstruction of optoacoustic images. Using phantoms and data from OPUS scans of human radial and carotid arteries, we show that ultrasound-driven optoacoustic inversion reduces limited-view artefacts and improves image contrast. In phantoms, prior-integrated reconstruction leads to a 50 higher contrast-to-noise ratio (CNR) of the image than standard reconstruction, and a 17 higher structural similarity (SSIM) index. In clinical data, prior-integrated reconstruction detects deep-seated radial arteries with higher CNR than the standard method at three different depths. In this way, the prior-integrated method offers unique insights into atherosclerotic carotid plaques in humans (with p<0.01 between patients and healthy volunteers), potentially paving the way for new abilities in vascular imaging and more generally in optoacoustic imaging. © 2020 The Authors

Item Type: Journal Article
Publication: Photoacoustics
Publisher: Elsevier GmbH
Additional Information: Copyright of this article belongs to Elsevier GmbH
Keywords: Image reconstruction; Laplace transforms; Phantoms; Photoacoustic effect; Ultrasonics, Carotid; Contrast to noise ratio; Hybrid imaging; Laplacian regularizations; Radial artery; Structural information; Structural similarity indices (SSIM); Ultrasound detectors, Image enhancement
Department/Centre: Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics
Date Deposited: 09 Apr 2021 10:51
Last Modified: 09 Apr 2021 10:51
URI: http://eprints.iisc.ac.in/id/eprint/65104

Actions (login required)

View Item View Item