Yang, H and Jüstel, D and Prakash, J and Karlas, A and Helfen, A and Masthoff, M and Wildgruber, M and Ntziachristos, V (2020) Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging. In: Photoacoustics, 19 .
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Abstract
Using the same ultrasound detector, hybrid optoacoustic-ultrasound (OPUS) imaging provides concurrent scans of tissue slices or volumes and visualizes complementary sound- and light-based contrast at similar resolutions. In addition to the benefit of hybrid contrast, spatial co-registration enables images from one modality to be employed as prior information for improving an aspect of the performance of the other modality. We consider herein a handheld OPUS system and utilize structural information from ultrasound images to guide regional Laplacian regularization-based reconstruction of optoacoustic images. Using phantoms and data from OPUS scans of human radial and carotid arteries, we show that ultrasound-driven optoacoustic inversion reduces limited-view artefacts and improves image contrast. In phantoms, prior-integrated reconstruction leads to a 50 higher contrast-to-noise ratio (CNR) of the image than standard reconstruction, and a 17 higher structural similarity (SSIM) index. In clinical data, prior-integrated reconstruction detects deep-seated radial arteries with higher CNR than the standard method at three different depths. In this way, the prior-integrated method offers unique insights into atherosclerotic carotid plaques in humans (with p<0.01 between patients and healthy volunteers), potentially paving the way for new abilities in vascular imaging and more generally in optoacoustic imaging. © 2020 The Authors
| Item Type: | Journal Article |
|---|---|
| Publication: | Photoacoustics |
| Publisher: | Elsevier GmbH |
| Additional Information: | Copyright of this article belongs to Elsevier GmbH |
| Keywords: | Image reconstruction; Laplace transforms; Phantoms; Photoacoustic effect; Ultrasonics, Carotid; Contrast to noise ratio; Hybrid imaging; Laplacian regularizations; Radial artery; Structural information; Structural similarity indices (SSIM); Ultrasound detectors, Image enhancement |
| Department/Centre: | Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics |
| Date Deposited: | 09 Apr 2021 10:51 |
| Last Modified: | 09 Apr 2021 10:51 |
| URI: | http://eprints.iisc.ac.in/id/eprint/65104 |
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