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Multiscale modeling of vertebrate limb development

Glimm, T and Bhat, R and Newman, SA (2020) Multiscale modeling of vertebrate limb development. In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 12 (4).

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Official URL: https://doi.org/10.1002/wsbm.1485


We review the current state of mathematical modeling of cartilage pattern formation in vertebrate limbs. We place emphasis on several reaction�diffusion type models that have been proposed in the last few years. These models are grounded in more detailed knowledge of the relevant regulatory processes than previous ones but generally refer to different molecular aspects of these processes. Considering these models in light of comparative phylogenomics permits framing of hypotheses on the evolutionary order of appearance of the respective mechanisms and their roles in the fin-to-limb transition. This article is categorized under: Analytical and Computational Methods > Computational Methods Models of Systems Properties and Processes > Mechanistic Models Developmental Biology > Developmental Processes in Health and Disease Analytical and Computational Methods > Analytical Methods. © 2020 Wiley Periodicals, Inc.

Item Type: Journal Article
Publication: Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Publisher: Wiley-Blackwell
Additional Information: Copyright for this article belongs to Wiley
Keywords: BMP, fin-limb transition, galectin, Turing-type mechanism, Wnt
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 21 Apr 2021 09:19
Last Modified: 21 Apr 2021 09:19
URI: http://eprints.iisc.ac.in/id/eprint/65072

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