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Emerging trends in the development of plant virus-based nanoparticles and their biomedical applications

Hema, M and Vishnu Vardhan, GP and Savithri, HS and Murthy, RNM (2018) Emerging trends in the development of plant virus-based nanoparticles and their biomedical applications. [Book Chapter]

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Official URL: https://doi.org/10.1016/B978-0-12-816328-3.09988-8


Viral nanobiotechnology is an emerging and fascinating field, dealing with the use of virus-based nanoparticles as templates and/or building blocks to display novel molecular moieties with specific properties for a wide range of applications in biology, medicine, and materials science. Viral nanoparticles (VNPs) and virus like particles (VLPs) are naturally occurring highly organized, programmable nanoassemblies that provide excellent platforms for nanoscale fabrication due to their unique physical and chemical properties. Plant virus-based nanoparticles (PVNs-VNPs and VLPs derived from plant viruses) have been explored for several years either to express subunit vaccines or as epitope presentation systems. In the recent times, these PVNs are attracting the attention of researchers and clinicians due to their several attractive features such as size range (nanometer), relative structural stability, high degree of symmetry, polyvalency, monodispersity, noninfectious and nonhazardous nature when injected to mammals, low cost of production, and biocompatibility. VNPs and VLPs can readily be engineered chemically and genetically to carry targeting ligands, therapeutic antibodies, and imaging agents and drugs on their exterior and interior surfaces. This review aims to summarize important plant virus-based nanomaterials (icosahedral and helical shaped) that have been developed for imaging, drug delivery, and therapeutic applications. © 2019 Elsevier Inc. All rights reserved.

Item Type: Book Chapter
Publication: Recent Developments in Applied Microbiology and Biochemistry
Publisher: Elsevier
Additional Information: Copyright of this book chapter belongs to Elsevier
Department/Centre: Division of Biological Sciences > Biochemistry
Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 22 Apr 2021 11:18
Last Modified: 22 Apr 2021 11:18
URI: http://eprints.iisc.ac.in/id/eprint/65033

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