Kumar, SRS and Shastri, SL and Venkatesh, R and Pradeepa, K and Krishna, V (2019) Antibacterial potential of Caesalpinia bonducella extracts and their isolated phytoconstituents: In vitro and in silico analysis. In: Journal of Applied Biology and Biotechnology, 7 (3). pp. 41-46.
|
PDF
jou_app_bio_biot_7-3_41-46_2019.pdf - Published Version Download (1MB) | Preview |
Abstract
The antimicrobial activity of Caesalpinia bonducella extracts such as CLC, CLE, CSC, and CSE and the phytoconstituents such as β-Sitosterol (LC3) isolated from CLC and methyl (4E)-5-2-(1E)-buta-1,3-dien-1-yl-4,6-dihydroxyphenyl pent-4-enoate (SC2) isolated from CSC were evaluated on gram-positive and gram-negative bacteria. The extracts and isolated compounds were found to have moderate-to-significant bacterial inhibition. The significant activity was observed in the inhibition of Pseudomonas aeruginosa by CLC extract (16.10 ± 1.10 mm), whereas the isolated phytocomponent SC2 showed the highest inhibition (16.50 ± 0.58 mm). Further, the isolated compounds were subjected to molecular docking studies of the bacterial DNA Gyrase. The in silico study showed the docking energy of �6.4 and three hydrogen bonding. This in vitro and in silico analysis of extracts and isolated phytocomponents of C. bonducella helps to understand and evaluate the therapeutic efficacy to cure infectious diseases and also supports the traditional medicinal claim as an antibiotic. © 2019 Kumar, et al.
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Applied Biology and Biotechnology |
| Publisher: | Open Science Publishers LLP Inc. |
| Additional Information: | Copyright of this article belongs to 2019 Kumar, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 26 May 2021 11:01 |
| Last Modified: | 26 May 2021 11:18 |
| URI: | http://eprints.iisc.ac.in/id/eprint/65015 |
Actions (login required)
 |
View Item |
