Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides

Verma, PK and Prasad, KS and Varghese, D and Geetharani, K (2020) Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides. In: Organic Letters, 22 (4). pp. 1431-1436.

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Abstract

A cobalt-complex-catalyzed borylation of a wide range of alkyl halides with a diboron reagent (B2pin2 or B2neop2) has been developed under mild reaction conditions, demonstrating the first cobalt-mediated cross-coupling with alkyl electrophiles. This protocol allows alkyl boronic esters to be accessed from alkyl halides, including alkyl chlorides, which were used rarely as coupling partners. Mechanistic studies reveal the possible involvement of an alkyl radical intermediate in this cobalt-mediated catalytic cycle. Copyright © 2020 American Chemical Society.

Item Type:	Journal Article
Publication:	Organic Letters
Publisher:	American Chemical Society
Additional Information:	The copyright of thisa rticle belongs to American Chemical Society
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	11 Aug 2020 11:07
Last Modified:	11 Aug 2020 11:07
URI:	http://eprints.iisc.ac.in/id/eprint/64875

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