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Ameliorating effect of glutathione-enriched herbal formulation (glothione) on alloxan-induced experimental diabetic model by modulating oxidative stress and pathogenesis

Sreevallabhan, S and Mohanan, R and Sukumaran, S and Sobha, AP and Jose, SP and Sukumarapillai, A and Jagmag, T and Tilwani, J (2020) Ameliorating effect of glutathione-enriched herbal formulation (glothione) on alloxan-induced experimental diabetic model by modulating oxidative stress and pathogenesis. In: Journal of Food Biochemistry, 44 (4).

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Official URL: https://doi.org/10.1111/jfbc.13153


Diabetes Mellitus is a common metabolic or endocrine disorder that occurs as a result of insufficient amounts of insulin secretion or defect in the action of insulin produced from pancreatic beta cells. Antioxidant containing food items are very effective in reducing complications that arise due to diabetes, indicating that it may be beneficial for treating metabolic disorders. In this study, we used some essential nutrients enriched with glutathione, named as Glothione (GN), and evaluated the antidiabetic effect of GN in alloxan-induced diabetic rats. The treatment with GN showed significant reduction in the blood glucose level, HbA1c level, and liver markers like SGOT, SGPT, and ALP and shows increased antioxidant status and decreased inflammatory markers. Histopathological analysis of pancreas and liver tissue showed that there were no abnormalities in the rat after the administration of GN. Thus, antioxidant-enriched formulation of GN can be used as a potent hypoglycaemic drug. Practical applications: Glothione is a glutathione-enriched formulation that contains essential nutrients required for the normal functioning of the body. Recent trends in lifestyle and food habits have been noted to cause health risks and subject the body through physical and physiological stress��hence the importance of antioxidant-rich foods. Antioxidants are capable of boosting metabolism and other physiological processes. Thus, the consumption of GN can enhance the antioxidant status within the body. GN does not contain any chemical ingredients so it will not cause any side effects. It has a strong antidiabetic effect and is also able to control a number of diseases. © 2020 Wiley Periodicals, Inc.

Item Type: Journal Article
Publication: Journal of Food Biochemistry
Publisher: Blackwell Publishing Ltd.
Additional Information: Copyright of this article belongs to Blackwell Publishing Ltd
Keywords: Disease control; Health risks; Insulin; Metabolism; Nutrients; Oxidative stress; Peptides; Physiology, Antidiabetic effects; Chemical ingredients; Diabetes mellitus; glothione; Histopathological analysis; Pancreatic beta cells; Physiological process; Physiological stress, Antioxidants
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 22 Apr 2021 10:07
Last Modified: 22 Apr 2021 10:07
URI: http://eprints.iisc.ac.in/id/eprint/64656

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