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Cyclic nucleotides, gut physiology and inflammation

Prasad, H and Shenoy, AR and Visweswariah, SS (2020) Cyclic nucleotides, gut physiology and inflammation. In: FEBS Journal .

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Official URL: http://dx.doi.org/10.1111/febs.15198


Misregulation of gut function and homeostasis impinges on the overall well-being of the entire organism. Diarrheal disease is the second leading cause of death in children under 5 years of age, and globally, 1.7 billion cases of childhood diarrhea are reported every year. Accompanying diarrheal episodes are a number of secondary effects in gut physiology and structure, such as erosion of the mucosal barrier that lines the gut, facilitating further inflammation of the gut in response to the normal microbiome. Here, we focus on pathogenic bacteria-mediated diarrhea, emphasizing the role of cyclic adenosine 3',5'-monophosphate and cyclic guanosine 3�,5�-monophosphate in driving signaling outputs that result in the secretion of water and ions from the epithelial cells of the gut. We also speculate on how this aberrant efflux and influx of ions could modulate inflammasome signaling, and therefore cell survival and maintenance of gut architecture and function.

Item Type: Journal Article
Publication: FEBS Journal
Publisher: Blackwell Publishing Ltd
Additional Information: Copyright of this article belongs to Blackwell Publishing Ltd
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 17 Feb 2020 11:34
Last Modified: 17 Feb 2020 11:34
URI: http://eprints.iisc.ac.in/id/eprint/64566

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