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Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression

Jolly, Mohit Kumar and Celià-Terrassa, Toni (2019) Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression. In: Journal of Clinical Medicine, 8 (10). p. 1542. ISSN 2077-0383

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Official URL: http://doi.org/10.3390/jcm8101542


Genetic and phenotypic heterogeneity contribute to the generation of diverse tumor cell populations, thus enhancing cancer aggressiveness and therapy resistance. Compared to genetic heterogeneity, a consequence of mutational events, phenotypic heterogeneity arises from dynamic, reversible cell state transitions in response to varying intracellular/extracellular signals. Such phenotypic plasticity enables rapid adaptive responses to various stressful conditions and can have a strong impact on cancer progression. Herein, we have reviewed relevant literature on mechanisms associated with dynamic phenotypic changes and cellular plasticity, such as epithelial-mesenchymal transition (EMT) and cancer stemness, which have been reported to facilitate cancer metastasis. We also discuss how non-cell-autonomous mechanisms such as cell-cell communication can lead to an emergent population-level response in tumors. The molecular mechanisms underlying the complexity of tumor systems are crucial for comprehending cancer progression, and may provide new avenues for designing therapeutic strategies.

Item Type: Journal Article
Publication: Journal of Clinical Medicine
Publisher: MDPI
Additional Information: Copyright of this article belongs to MDPI
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 20 Dec 2019 10:39
Last Modified: 20 Dec 2019 10:39
URI: http://eprints.iisc.ac.in/id/eprint/64179

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