Cobalt-Catalyzed Regioselective 4+2] Annulation/Lactonization of Benzamides with 4-Hydroxy-2-Alkynoates under Aerobic Conditions

Muniraj, Nachimuthu and Kumar, Anil and Prabhu, Kandikere Ramaiah (2019) Cobalt-Catalyzed Regioselective 4+2] Annulation/Lactonization of Benzamides with 4-Hydroxy-2-Alkynoates under Aerobic Conditions. In: ADVANCED SYNTHESIS & CATALYSIS .

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Abstract

A cobalt-catalyzed regioselective 4+2] annulation/lactonization reaction of benzamides with 4-hydroxy-2-alkynoates is reported. This reaction utilizes air as an oxidant rather than metal salts. The method is operationally simple, mild, and sustainable. This protocol exhibits a broad substrate scope and compatible with a variety of functional groups furnishing the corresponding 1,4-dihydrofuro3,4-c]isoquinoline-3,5-dione derivatives in good to excellent yields with high regioselectivity.

Item Type:	Journal Article
Publication:	ADVANCED SYNTHESIS & CATALYSIS
Publisher:	WILEY-V C H VERLAG GMBH
Additional Information:	Copyright of this article belongs to WILEY-V C H VERLAG GMBH
Keywords:	C-H activation; cobalt; [4+2] annulation; lactonization; regioselective; aerobic condition
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	18 Dec 2019 06:17
Last Modified:	18 Dec 2019 06:17
URI:	http://eprints.iisc.ac.in/id/eprint/64040

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