Ayyub, Shreya Ahana and Varshney, Umesh (2019) Translation initiation in mammalian mitochondria- a prokaryotic perspective. In: RNA BIOLOGY .
Full text not available from this repository. (Request a copy)Abstract
ATP is generated in mitochondria of eukaryotic cells by oxidative phosphorylation (OXPHOS). The OXPHOS complex, which is crucial for cellular metabolism, comprises of both nuclear and mitochondrially encoded subunits. Also, the occurrence of several pathologies because of mutations in the mitochondrial translation apparatus indicates the importance of mitochondrial translation and its regulation. The mitochondrial translation apparatus is similar to its prokaryotic counterpart due to a common origin of evolution. However, mitochondrial translation has diverged from prokaryotic translation in many ways by reductive evolution. In this review, we focus on mammalian mitochondrial translation initiation, a highly regulated step of translation, and present a comparison with prokaryotic translation.
| Item Type: | Journal Article |
|---|---|
| Publication: | RNA BIOLOGY |
| Publisher: | TAYLOR & FRANCIS INC |
| Additional Information: | Copyright of this article belongs to TAYLOR & FRANCIS INC |
| Keywords: | TRANSFER-RNA; RIBOSOMAL-PROTEINS; ELONGATION-FACTORS; TERMINAL EXTENSIONS; MESSENGER-RNAS; START-CODON; WEIGHT-LOSS; FACTOR-III; YEAST; MUTATION |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
| Date Deposited: | 07 Feb 2020 10:38 |
| Last Modified: | 07 Feb 2020 10:38 |
| URI: | http://eprints.iisc.ac.in/id/eprint/64000 |
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