Dynamics of physiologically relevant noncanonical DNA structures: an overview from experimental and theoretical studies

Ghoshdastidar, Debostuti and Bansal, Manju (2019) Dynamics of physiologically relevant noncanonical DNA structures: an overview from experimental and theoretical studies. In: BRIEFINGS IN FUNCTIONAL GENOMICS, 18 (3). pp. 192-204.

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Abstract

DNA is a complex molecule with phenomenal inherent plasticity and the ability to form different hydrogen bonding patterns of varying stabilities. These properties enable DNA to attain a variety of structural and conformational polymorphic forms. Structurally, DNA can exist in single-stranded form or as higher-order structures, which include the canonical double helix as well as the noncanonical duplex, triplex and quadruplex species. Each of these structural forms in turn encompasses an ensemble of dynamically heterogeneous conformers depending on the sequence composition and environmental context. In vivo, the widely populated canonical B-DNA attains these noncanonical polymorphs during important cellular processes. While several investigations have focused on the structure of these noncanonical DNA, studying their dynamics has remained nontrivial. Here, we outline findings from some recent advanced experimental and molecular simulation techniques that have significantly contributed toward understanding the complex dynamics of physiologically relevant noncanonical forms of DNA.

Item Type:	Journal Article
Publication:	BRIEFINGS IN FUNCTIONAL GENOMICS
Publisher:	OXFORD UNIV PRESS
Additional Information:	Copyright of this article belongs to OXFORD UNIV PRESS
Keywords:	dynamics of noncanonical DNA; NMR spectroscopy; molecular dynamics simulations; DNA structural polymorphism; DNA conformational polymorphism; higher-order DNA structure
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	31 Jan 2020 06:02
Last Modified:	31 Jan 2020 06:02
URI:	http://eprints.iisc.ac.in/id/eprint/63990

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