Immunological implications of epidermal growth factor receptor signaling in persistent infections

Mukherjee, Tanushree and Balaji, Kithiganahalli Narayanaswamy (2019) Immunological implications of epidermal growth factor receptor signaling in persistent infections. In: IUBMB LIFE . pp. 1-11.

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Abstract

Infectious diseases account for a large proportion of global health emergencies and are rising more so owing to the paucity of effective vaccination and chemotherapeutic strategies. The severity is compounded by the development of antibiotic resistance among major pathogenic strains, capable of residing in the hostile host microenvironment by hijacking its signaling mechanisms and molecular circuitry. Among such processes, studies on epidermal growth factor receptor (EGFR) have revealed specific contributions of this classical oncogenic signaling axis during distinct infection conditions. Here, we review the current status of EGFR family members in the context of host-pathogen interactions and speculate the possible dimensions of exploration and manipulation of the EGFR pathway for host-directed therapeutic purposes.

Item Type:	Journal Article
Publication:	IUBMB LIFE
Publisher:	WILEY
Additional Information:	copyright for this article belongs to 2019 International Union of Biochemistry and Molecular Biology.
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	21 Aug 2019 07:29
Last Modified:	31 Aug 2019 16:26
URI:	http://eprints.iisc.ac.in/id/eprint/63422

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