Iodide as a Nucleophilic Trigger in Aryne Three-Component Coupling for the Synthesis of 2-lodobenzyl Alcohols

Bhattacharjee, Subrata and Guin, Avishek and Gaykar, Rahul N and Biju, Akkattu T (2019) Iodide as a Nucleophilic Trigger in Aryne Three-Component Coupling for the Synthesis of 2-lodobenzyl Alcohols. In: ORGANIC LETTERS, 21 (11). pp. 4383-4387.

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Abstract

The synthetic potential of KI as the iodide source in aryne three-component coupling has been demonstrated using aldehydes as the third component. This mild and transition-metal free coupling reaction allowed the straightforward synthesis of 2-iodobenzyl alcohols in moderate to good yields with good functional group compatibility. Moreover, KBr and KCl could be used as the nucleophilic trigger in this aryne multicomponent coupling (MCC) and N-methylisatin and CO2 could be used as the electrophilic third components.

Item Type:	Journal Article
Publication:	ORGANIC LETTERS
Publisher:	AMER CHEMICAL SOC
Additional Information:	The copyright of this article belongs to AMER CHEMICAL SOC
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	05 Jul 2019 07:19
Last Modified:	05 Jul 2019 07:19
URI:	http://eprints.iisc.ac.in/id/eprint/63130

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