Visible-Light-Mediated Direct Decarboxylative Acylation of Electron-Deficient Heteroarenes Using alpha-Ketoacids

Manna, Sabyasachi and Prabhu, Kandikere Ramaiah (2019) Visible-Light-Mediated Direct Decarboxylative Acylation of Electron-Deficient Heteroarenes Using alpha-Ketoacids. In: JOURNAL OF ORGANIC CHEMISTRY, 84 (9). pp. 5067-5077.

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Abstract

Acylation of electron-deficient heteroaromatic compounds has been developed using visible light. alpha-Ketoacids have been used as an efficient source of acyl radicals under photoredox conditions. The in situ generated acyl radicals from alpha-ketoacids have been coupled to a wide variety of electron-deficient heteroaromatic compounds in a Minisci type reaction. This method would be attractive to access biologically attractive molecules.

Item Type:	Journal Article
Publication:	JOURNAL OF ORGANIC CHEMISTRY
Publisher:	AMER CHEMICAL SOC
Additional Information:	copyright for this article belongs to JOURNAL OF ORGANIC CHEMISTRY
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	24 Jun 2019 18:08
Last Modified:	24 Jun 2019 18:08
URI:	http://eprints.iisc.ac.in/id/eprint/63067

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