Heterogeneous network dynamics in an excitatory-inhibitory network model by distinct intrinsic mechanisms in the fast spiking interneurons

Dasgupta, Debanjan and Sikdar, Sujit Kumar (2019) Heterogeneous network dynamics in an excitatory-inhibitory network model by distinct intrinsic mechanisms in the fast spiking interneurons. In: BRAIN RESEARCH, 1714 . pp. 27-44.

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Abstract

Fast spiking interneurons (FSINs) have an important role in neuronal network dynamics. Although plasticity of synaptic properties is known to affect network synchrony, the role of plasticity of FSINs' intrinsic excitability on network dynamics remain elusive. Using computational approaches in an excitatory-FSIN model network (ED based on previously established hippocampal neuronal models we show that altered FSIN intrinsic excitability robustly affects the coherence and frequency of network firing monotonically in the connected excitatory network. Surprisingly, the effect of FSIN excitability was dependent on the mechanisms associated with changes in intrinsic excitability rather than on the direction of the change. Decreasing FSIN excitability by decreasing the membrane specific resistance (R-m), increasing peak HCN conductance (g(ih)bar) increased the excitatory network coherence while increased peak delayed potassium conductance (g(KD)bar) decreased the coherence. However, the perturbations affected the excitatory network frequency in a similar manner. Further, in an isolated FSIN all-to all network (II), decreasing FSIN excitability caused significant decrease in the network steady-state frequency due to any of the alterations. However, II network coherence remained unaltered with change in FSIN R-in but increased with higher g(KD)bar and lower g(KD)bar. Interestingly, decreased FSIN R-m could partially rescue the decreasing El network coherence with increasing g(KD)bar. The phenomenon of FSIN R-m, g(KD)bar and giwbar dependent El network coherence alterations was robust for different proportions of plastic FSINs. Our results indicate that plasticity of intrinsic excitability in FSINs can regulate network dynamics and thus serve as an important network strategy during different physiological states.

Item Type:	Journal Article
Publication:	BRAIN RESEARCH
Publisher:	ELSEVIER SCIENCE BV
Additional Information:	copyright for this article belongs to Elsevier B.V.
Keywords:	Network simulation; Fast-spiking interneuron; Intrinsic plasticity
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	10 Jun 2020 07:28
Last Modified:	10 Jun 2020 07:28
URI:	http://eprints.iisc.ac.in/id/eprint/62857

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