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Hoodwinking the Big-Eater to Prosper: The Salmonella-Macrophage Paradigm

Gogoi, Mayuri and Shreenivas, Meghanashree M and Chakravortty, Dipshikha (2018) Hoodwinking the Big-Eater to Prosper: The Salmonella-Macrophage Paradigm. In: JOURNAL OF INNATE IMMUNITY, 11 (3). pp. 289-299.

J_Innate_Immunology_11_289-299_2019.pdf - Published Version

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Official URL: https://dx.doi.org/10.1159/000490953


Salmonella is a major cause of morbidity and mortality in the developing and underdeveloped nations. Being a food-borne disease, Salmonella infection is primarily contracted through the ingestion of contaminated food or water, or due to close contact with infected/carrier individuals. It is an intracellular pathogen, which can survive and replicate in various cells including macrophages, dendritic cells, epithelial cells, and other white blood cells. Once Salmonella crosses the intestinal barrier, it disseminates to various systemic sites by circulation via immune cells. One of the major cell types which are involved in Salmonella infection are host macrophages. They are the niche for intracellular survival and proliferation of Salmonella and a mode of dissemination to distal systemic sites. These cells are very crucial as they mediate the mounting of an appropriate innate and adaptive anti-Salmonella immune response. In this review, we have tried to concise the current knowledge of complex interactions that occur between Salmonella and macrophages. (C) 2018 The Author(s) Published by S. Karger AG, Basel

Item Type: Journal Article
Publisher: KARGER
Additional Information: The copyright for this article belongs to KARGER
Keywords: Macrophage; TLR; NLR; ROS; Pyroptosis; Metal starvation; AMP; Exosome
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
UG Programme
Date Deposited: 03 Jun 2019 10:40
Last Modified: 03 Jun 2019 10:40
URI: http://eprints.iisc.ac.in/id/eprint/62812

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