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DNA Translocation through Hybrid Bilayer Nanopores

Balasubramanian, Ramkumar and Pal, Sohini and Joshi, Himanshu and Rao, Anjana and Naik, Akshay and Varma, Manoj and Chakraborty, Banani and Maiti, Prabal K (2019) DNA Translocation through Hybrid Bilayer Nanopores. In: JOURNAL OF PHYSICAL CHEMISTRY C, 123 (18). pp. 11908-11916.

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Official URL: https://dx.doi.org/10.1021/acs.jpcc.9b00399


Pore functionalization has been explored by several groups as a strategy to control DNA translocation through solid-state nanopores. Here we present a hybrid nanopore system consisting of single-layer graphene and a DNA origami layer to achieve base-selective control of DNA translocation rate through aligned nanopores of the two layers. This is achieved by incorporating unpaired dangling bases called overhangs to the origami near the pore region. Molecular dynamics simulations were used to optimize the design of the origami nanopore and the overhangs. Specifically, we considered the influence of the number and spatial distribution of overhangs on translocation times. The simulations revealed that specific interactions between the overhangs and the translocating single-stranded DNA resulted in base-specific residence times.

Item Type: Journal Article
Additional Information: The copyright for this article belongs to AMER CHEMICAL SOC
Department/Centre: Division of Mechanical Sciences > Chemical Engineering
Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering
Division of Physical & Mathematical Sciences > Physics
Date Deposited: 03 Jun 2019 11:35
Last Modified: 03 Jun 2019 11:35
URI: http://eprints.iisc.ac.in/id/eprint/62773

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