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Molecular pathways regulated by areca nut in the etiopathogenesis of oral submucous fibrosis

Kondaiah, Paturu and Pant, Ila and Khan, Imran (2019) Molecular pathways regulated by areca nut in the etiopathogenesis of oral submucous fibrosis. In: PERIODONTOLOGY 2000, 80 (1). pp. 213-224.

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Official URL: https://dx.doi.org/10.1111/prd.12266


Many oral mucosal lesions are due to substance abuse, such as tobacco and areca nut, amongst others. There is considerable evidence that oral lesions/disorders such as some leukoplakias, most erythroplakias, and submucous fibrosis have malignant potential, with a conversion rate of 5%-10% over a 10-year period. There have been several reports on possible biomarkers that predict malignant conversion of the oral lesions associated with these disorders. Management of these is mostly surgical removal of the lesion followed by observation, and in some cases treatment by antioxidants and anti-inflammatory agents. Oral submucous fibrosis is due to excessive deposition of extracellular matrix in the connective tissue plus, particularly, collagens. The deposition of collagen leads to stiffness of the affected regions and results in difficulty in mouth opening. Areca nut chewing is proposed as the most probable etiological factor in the manifestation of oral submucous fibrosis. Several studies suggest involvement of proinflammatory cytokines, dysregulated by areca nut, in the development of the disease. Amongst these, transforming growth factor-beta is in the forefront, which is also shown to be involved in fibrosis of other organs. This review addresses the molecular mechanisms involved in oral submucous fibrosis development and provides a model for the regulation of transforming growth factor-beta by areca nut. It provides an exemplar of the role of modern molecular techniques in the study of oral disease.

Item Type: Journal Article
Publication: PERIODONTOLOGY 2000
Publisher: WILEY
Additional Information: The copyright for this article belongs to Blackwell Munksgaard
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 18 Jul 2019 10:02
Last Modified: 18 Jul 2019 10:02
URI: http://eprints.iisc.ac.in/id/eprint/62766

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